| Identification | Back Directory | [Name]
N3-PEG5-CH2COOH | [CAS]
217180-81-9 | [Synonyms]
217180-81-9
N3-PEG5-CH2CO2H
N3-PEG5-CH2COOH
Azido-PEG5-CH2CO2H
Azido-PEG5-CH2COOH
AZIDE-PEG5-CH2COOH | [Molecular Formula]
C12H23N3O7 | [MDL Number]
MFCD31561141 | [MOL File]
217180-81-9.mol | [Molecular Weight]
321.33 |
| Hazard Information | Back Directory | [Description]
Azido-PEG5-CH2CO2H is a water soluble PEG linker. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide. | [Uses]
Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Cleavable Linker; PEGs | [References]
[1] Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1. |
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