| Identification | Back Directory | [Name]
Atorvastatin tert-Butyl Ester | [CAS]
134395-00-9 | [Synonyms]
(3R,5R)
Atorvastatin 1
Atorvastatin Impurity 21
Atorvastatin t-butyl ester
Atorvastatin tert-Butyl Ester
-tert-Butyl 7-(2-(4-fluorophenyl)
(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-
(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)
(R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole
(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbaMoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
7-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5- dihydroxy-heptanoic Acid tert-Butyl Ester
(3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid tert-butyl ester
(R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester
(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-DiMethylethyl Ester
1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-, 1,1-diMethylethyl ester, (βR,δR)-
(4R-cis)-1,1-diMethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-isopropyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrro-1-yl]ethyl]-2,2-diMethyl-1,3-dihydroxy-4-acetate | [EINECS(EC#)]
603-817-6 | [Molecular Formula]
C37H43FN2O5 | [MDL Number]
MFCD09839952 | [MOL File]
134395-00-9.mol | [Molecular Weight]
614.746 |
| Chemical Properties | Back Directory | [Appearance]
Off-white to pale yellow solid | [Melting point ]
66-68°C | [Boiling point ]
721.0±60.0 °C(Predicted) | [density ]
1.16 | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.57±0.70(Predicted) | [color ]
White to Off-White | [PH]
6.22 at 25℃ and 10mg/L | [Major Application]
pharmaceutical small molecule | [InChIKey]
GCPKKGVOCBYRML-LOYHVIPDSA-N | [SMILES]
Fc1ccc(cc1)c2[n](c(c(c2c4ccccc4)C(=O)Nc3ccccc3)C(C)C)CC[C@@H](O)C[C@@H](O)CC(=O)OC(C)(C)C | [CAS DataBase Reference]
134395-00-9 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white to pale yellow solid | [Uses]
An impurity arising in the synthesis of Atorvastatin | [Synthesis]
Firstly, 90mL of methanol and compound L1 were put into a 250mL three-necked bottle.
10g into a 250mL three-necked bottle, slowly add 15% hydrochloric acid solution dropwise, the reaction at 35 ℃ for 2h, TLC to monitor the raw material reaction is comple |
| Safety Data | Back Directory | [Hazard statements ]
H413 | [WGK Germany ]
WGK 2 | [REACH Registrations]
Active | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Chronic 2
STOT RE 2 |
|
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J & K SCIENTIFIC LTD.
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NCE Biomedical Co.,Ltd.
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