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1346013-80-6

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1346013-80-6 Structure

1346013-80-6 Structure
IdentificationBack Directory
[Name]

UE2343
[CAS]

1346013-80-6
[Synonyms]

UE2343
Xanamen
UE2343(Xanamem)
[Molecular Formula]

C19H19N5O2S
[MOL File]

1346013-80-6.mol
[Molecular Weight]

381.45
Chemical PropertiesBack Directory
[Boiling point ]

685.9±55.0 °C(Predicted)
[density ]

1.448±0.06 g/cm3(Predicted)
[pka]

13.08±0.20(Predicted)
Hazard InformationBack Directory
[Description]

UE2343 (Xanamem) is a potent, orally bioavailable, brain-penetrant 11β-HSD1 inhibitor.
[Uses]

UE2343 is an orally available, brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. UE2343 is being investigated for the treatment of Alzheimer's disease[1].
[References]

[1] Webster S P, et al. Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem?)[J]. British Journal of Pharmacology, 2017, 174(5): 396-408. DOI:10.1111/bph.13699
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