| Identification | Back Directory | [Name]
CID-49830258 | [CAS]
1346527-98-7 | [Synonyms]
ML240
CS-2775
ML240, >98%
CID-49830258
ML240 >=98% (HPLC)
2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine
2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)- | [Molecular Formula]
C23H20N6O | [MDL Number]
MFCD28137687 | [MOL File]
1346527-98-7.mol | [Molecular Weight]
396.44 |
| Chemical Properties | Back Directory | [Boiling point ]
696.6±65.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
4.53±0.10(Predicted) | [color ]
white to yellow to light brown | [InChI]
1S/C23H20N6O/c1-30-19-13-7-10-16-20(19)27-23(28-21(16)25-14-15-8-3-2-4-9-15)29-18-12-6-5-11-17(18)26-22(29)24/h2-13H,14H2,1H3,(H2,24,26)(H,25,27,28) | [InChIKey]
NHAMBLRUUJAFOY-UHFFFAOYSA-N | [SMILES]
NC1=NC2=C(C=CC=C2)N1C3=NC4=C(OC)C=CC=C4C(NCC5=CC=CC=C5)=N3 |
| Hazard Information | Back Directory | [Uses]
ML 240 is a p97 inhibitor in cancer and neurodegenerative diseases. | [Uses]
ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein. | [Definition]
ChEBI: ML240 is a member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP). It has a role as an antineoplastic agent. It is a member of quinazolines, a member of benzimidazoles, a secondary amino compound, an aromatic amine, an aromatic ether and a primary amino compound. | [Biochem/physiol Actions]
ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines. | [storage]
Store at +4°C |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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