1346753-00-1

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1346753-00-1 Structure

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[Description] YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.
[Uses] YHO-13351 is the prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.
[References] [1] Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10(7):1252-63. DOI:10.1158/1535-7163.MCT-10-0874

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