| Identification | Back Directory | [Name]
YHO-13351 (free base) | [CAS]
912288-64-3 | [Synonyms]
YHO-13351 (free base)
YHO13351 FREE BASE;YHO 13351 FREE BASE
Glycine, N,N-diethyl-, 1-[5-[(1Z)-2-cyano-2-(3,4-dimethoxyphenyl)ethenyl]-2-thienyl]-4-piperidinyl ester | [Molecular Formula]
C26H33N3O4S | [MDL Number]
MFCD29917848 | [MOL File]
912288-64-3.mol | [Molecular Weight]
483.62 |
| Chemical Properties | Back Directory | [Boiling point ]
627.1±55.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.24±0.25(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
YHO-13351 free base is the prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP. | [References]
[1] Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10(7):1252-63. DOI:10.1158/1535-7163.MCT-10-0874
[2] Shishido Y, et al. ABCG2 inhibitor YHO-13351 sensitizes cancer stem/initiating-like side population cells to irinotecan. Anticancer Res. 2013 Apr;33(4):1379-86. PMID:23564776 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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