| Identification | Back Directory | [Name]
Propargyl-PEG9-alcohol | [CAS]
1351556-81-4 | [Synonyms]
CAS_1351556-81-4
Propargyl-PEG8-OH
Propargyl-PEG9-alcohol
3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yn-1-ol | [Molecular Formula]
C19H36O9 | [MDL Number]
MFCD28950752 | [MOL File]
1351556-81-4.mol | [Molecular Weight]
408.48 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG9-alcohol is a crosslinker that can participate in copper catalyzed azide-alkyne Click Chemistry reactions to form stable triazole linkage. The PEG spacer increases the hydrophilicity of the molecule in aqueous media. | [Uses]
Propargyl-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG8-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] Goswami LN, et al. Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: potential applications in bioconjugation and targeted drug delivery. Org Biomol Chem. 2013 Feb 21;11(7):1116-26. DOI:10.1039/c2ob26968f |
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