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BE-10988 is a DNA topoisomerase inhibitor. BE-10988 inhibits the growth of Doxorubicin (HY-15142A)-resistant and vincristine-resistant P388 mouse leukemia cell lines by increasing the formation of DNA topoisomerase complexes[1]. | [References]
[1] Oka H, et al. A NEW TOPOISOMERASE-II INHIBITOR, BE-10988, PRODUCED BY A STREPTOMYCETE I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION[J]. The Journal of Antibiotics, 1991, 44(5): 486-491. DOI:10.7164/antibiotics.44.486 |
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