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1600418-29-8

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1600418-29-8 Structure

1600418-29-8 Structure
IdentificationBack Directory
[Name]

Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-
[CAS]

1600418-29-8
[Synonyms]

MC-GGFG-DX8951
Trastuzumab Impurity 1
Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[(
Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-
[Molecular Formula]

C49 H51 F N8 O11
[MDL Number]

MFCD32201042
[MOL File]

1600418-29-8.mol
[Molecular Weight]

946.97
Chemical PropertiesBack Directory
[Boiling point ]

1410.7±65.0 °C(Predicted)
[density ]

1.48±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

11.18±0.40(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC)[1].
[in vivo]

In MC-GGFG-Exatecan, GGFG is known to release drugs into tumor tissue without releasing them into peripheral circulation[1].

[IC 50]

Camptothecins
[References]

[1] Nakada T, et al. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1542-1545. DOI:10.1016/j.bmcl.2016.02.020
Spectrum DetailBack Directory
[Spectrum Detail]

Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-(1600418-29-8)1HNMR
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