| Identification | Back Directory | [Name]
CX6258(HCL) | [CAS]
1353859-00-3 | [Synonyms]
CX6285
CX6258(HCL)
CX6258(HCL) USP/EP/BP
CX-6258 Hydrochloride
Pim-Kinase Inhibitor X
CX6258 hydrochloride PIM inhibitor CX-6258 HCL
CX6258 hydrochloride,Pim,CX6258,CX-6258,Pim kinases,4E-BP1,CX 6258 hydrochloride,Inhibitor,CX 6258,Bad,inhibit
(E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one hydrochloride
(3E)-5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-Indol-2-one, hydrochloride (1:1)
CX6258(HCL) 2H-Indol-2-one, 5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-, hydro | [Molecular Formula]
C26H24ClN3O3.HCl | [MOL File]
1353859-00-3.mol | [Molecular Weight]
498.4 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO:57.0(Max Conc. mg/mL);114.37(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.01(Max Conc. mM) | [form ]
Solid | [color ]
Orange to red |
| Hazard Information | Back Directory | [Uses]
CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor. | [in vivo]
CX-6258 (50-100 mg/kg; p.o; daily; over a period of 21 days) exhibits robust in vivo efficacy in two Pim kinases driven tumor models[1].
| Animal Model: | Nude mice, MV-4-11 xenograft models[1] | | Dosage: | 50 mg/kg, 100 mg/kg. | | Administration: | Oral administration; once daily; over a period of 21 days. | | Result: | Exhibitd dose dependent efficacy, with a 50 mg/kg dose producing 45% tumor growth inhibition (TGI) and a 100 mg/kg dose producing 75% TGI. |
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