| Identification | Back Directory | [Name]
WEHI-345 (analog) | [CAS]
1354825-62-9 | [Synonyms]
WEHI-345 alog
WEHI-345 (analog)
WEHI-345 analogue
Reaxys ID: 22174618
2-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-3-methyl- | [Molecular Formula]
C23H25N7O | [MOL File]
1354825-62-9.mol | [Molecular Weight]
415.49 |
| Chemical Properties | Back Directory | [Boiling point ]
688.0±55.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 30 mg/mL (72.20 mM) | [form ]
Solid | [pka]
12.67±0.46(Predicted) | [color ]
White to gray |
| Hazard Information | Back Directory | [Uses]
WEHI-345 analog is the analog of WEHI-345. WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation[1]. | [IC 50]
RIPK2 | [storage]
Store at -20°C | [References]
[1] Nachbur U, et al. A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production. Nat Commun. 2015 Mar 17;6:6442. DOI:10.1038/ncomms7442 |
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Musechem
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+1-800-259-7612 |
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www.musechem.com |
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BOC Sciences
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16314854226 |
| Website: |
www.bocsci.com |
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