| Identification | Back Directory | [Name]
LY 254155 | [CAS]
135503-67-2 | [Synonyms]
LY 254155
GQCXGHHHNACOGE-ACGXKRRESA-N
L-Glutamic acid, N-[[5-[2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl)ethyl]-2-thienyl]carbonyl]- (9CI) | [Molecular Formula]
C19H23N5O6S | [MDL Number]
MFCD00888840 | [MOL File]
135503-67-2.mol | [Molecular Weight]
449.48 |
| Hazard Information | Back Directory | [Uses]
LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively. | [in vivo]
LY 254155 is active against a broad panel of murine and human xenograft solid tumors. LY 254155 (5, 10, 20, and 40 mg/kg) inhibits murine C3H carcinoma growth in C3H mice, with % inhibition of tumor growth is 49%, 71%, 90%, and 94%, respectively[1]. | [storage]
Store at -20°C | [References]
[1] Habeck LL, et al. A novel class of monoglutamated antifolates exhibits tight-binding inhibition of humanglycinamide ribonucleotide formyltransferase and potent activity against solid tumors. Cancer Res. 1994 Feb 15;54(4):1021-6. PMID:8313357 |
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