| Identification | Back Directory | [Name]
T-3364366 | [CAS]
1356354-09-0 | [Synonyms]
T-3364366
N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3H,4H-thieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide
N-[2-[[3,4-Dihydro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-2-yl]thio]ethyl]acetamide | [Molecular Formula]
C18H16F3N3O3S2 | [MDL Number]
MFCD31726175 | [MOL File]
1356354-09-0.mol | [Molecular Weight]
443.46 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
15.66±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay[1]. | [storage]
Store at -20°C | [References]
[1] Ikuo Miyahisa, et al. T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time. ACS Med Chem Lett. 2016 Aug 10;7(9):868-72. DOI:10.1021/acsmedchemlett.6b00241 |
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| Company Name: |
R&D Systems, Inc
|
| Tel: |
18003437475 18003437475 |
| Website: |
www.rndsystems.com |
|