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1357576-48-7

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1357576-48-7 Structure

1357576-48-7 Structure
IdentificationBack Directory
[Name]

AZD4320
[CAS]

1357576-48-7
[Synonyms]

AZD4320
Benzamide, 4-[4-[(R)-(4'-chloro[1,1'-biphenyl]-2-yl)hydroxymethyl]-1-piperidinyl]-N-[[4-[[(1R)-3-[(2-hydroxyethyl)methylamino]-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-
[Molecular Formula]

C45H48ClF3N4O7S3
[MDL Number]

MFCD31657439
[MOL File]

1357576-48-7.mol
[Molecular Weight]

945.53
Chemical PropertiesBack Directory
[density ]

1.46±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 125 mg/mL (132.20 mM)
[form ]

Solid
[pka]

4.70±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively.
[IC 50]

BCL2: 17 nM (IC50, KPUM-UH1 cells); BCLxL: 17 nM (IC50, KPUM-UH1 cells)
[References]

[1] Takimoto-Shimomura T, et al. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Invest New Drugs. 2018 Jun 21. DOI:10.1007/s10637-018-0623-8
Spectrum DetailBack Directory
[Spectrum Detail]

AZD4320(1357576-48-7)1HNMR
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