| Identification | Back Directory | [Name]
AZD4320 | [CAS]
1357576-48-7 | [Synonyms]
AZD4320
Benzamide, 4-[4-[(R)-(4'-chloro[1,1'-biphenyl]-2-yl)hydroxymethyl]-1-piperidinyl]-N-[[4-[[(1R)-3-[(2-hydroxyethyl)methylamino]-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]- | [Molecular Formula]
C45H48ClF3N4O7S3 | [MDL Number]
MFCD31657439 | [MOL File]
1357576-48-7.mol | [Molecular Weight]
945.53 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (132.20 mM) | [form ]
Solid | [pka]
4.70±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively. | [IC 50]
BCL2: 17 nM (IC50, KPUM-UH1 cells); BCLxL: 17 nM (IC50, KPUM-UH1 cells) | [References]
[1] Takimoto-Shimomura T, et al. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Invest New Drugs. 2018 Jun 21. DOI:10.1007/s10637-018-0623-8 |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Wuhan Topule
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+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
| Company Name: |
cjbscvictory
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https://www.weikeqi-biotech.com/ |
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