| Chemical Properties | Back Directory | [Boiling point ]
699.4±55.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.73±0.46(Predicted) | [color ]
White to light brown |
| Hazard Information | Back Directory | [Definition]
ChEBI: 1-[(4S,7S,8R)-8-methoxy-4,7,10-trimethyl-11-oxo-5-[[4-(2-pyridinyl)phenyl]methyl]-2-oxa-5,10-diazabicyclo[10.4.0]hexadeca-1(12),13,15-trien-14-yl]-3-propan-2-ylurea is an azamacrocycle and a lactam. | [Biological Activity]
BRD-K98645985 is an inhibitor of BAF (mammalian SWI/SNF) transcriptional repression with EC50 of ~2.37 μM. It binds ARID1A-specific BAF complexes, prevents nucleosome localization, and potently reverses HIV-1 latency without T cell toxicity. | [in vitro]
BRD-K98645985 (30 μM; 18 hours) treatment shows a 5-fold increase in Bmi1 , 2.6-fold increase in Ring1 , and 3.3- fold decrease in Fgf4 .
BRD-K98645985 treatment shows a concentration dependent latency reversal in J-Lat T-cell line models. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting. | [target]
| BAF transcriptional repression < span> 2.37 μM (EC 50 ) | HIV-1 | | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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