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135842-15-8

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135842-15-8 Structure

135842-15-8 Structure
IdentificationBack Directory
[Name]

BIG ENDOTHELIN-1 (1-39) (RAT)
[CAS]

135842-15-8
[Synonyms]

BIG ENDOTHELIN 39 RAT
BIG ET-1 (1-39) (RAT)
BIG ENDOTHELIN-1 (RAT, 1-39)
BIG ENDOTHELIN-1 (1-39) (RAT)
CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-ARG-VAL-VAL-PRO-TYR-GLY-LEU-GLY-SER-PRO-SER-ARG-SER
H-CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-ARG-VAL-VAL-PRO-TYR-GLY-LEU-GLY-SER-PRO-SER-ARG-SER-OH
CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-VAL-ASN-THR-PRO-GLU-ARG-VAL-VAL-PRO-TYR-GLY-LEU-GLY-SER-PRO-SER-ARG-SER: CSCSSLMDKECVYFCHLDIIWVNTPERVVPYGLGSPSRSDISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11
[Molecular Formula]

C192H292N50O58S5
[MDL Number]

MFCD00151519
[Molecular Weight]

4389
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[form ]

Solid
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

Big endothelin-1(1-39) (RAT) is a 39 amino acid peptide, which is synthesized and secreted by vascular smooth muscle and endothelium cells. It is produced as an inactive enzyme, and is cleaved and activated by serine and aspartic proteases and metalloproteinases. Activated form is called ET-1, which is a potent vasoconstrictor. ET-1 is also produced by the action of endothelin converting enzyme (ECE) on big-ET-1. In guinea pigs, big-ET-1 causes the release of prostanoids and thromboxanes.
[Uses]

Big endothelin-1(1-39) (RAT) has been used for charting of a standard curve in the study of the role of ET-1 in ventricular dilatation.
[Biological Activity]

Precursor of Endothelin-1; vasoconstrictor activity appears to be due to its conversion to endothelin 1 by endothelin converting enzyme in the tissue.
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