| Identification | Back Directory | [Name]
4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride | [CAS]
136647-02-4 | [Synonyms]
UK-78282 HCl
UK 78282 hydrochloride
UK-78282 monohydrochloride
UK-78282 monohydrochloride >=98% (HPLC)
4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-pi
4-(Benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine
4-(3,3-diphenylpropyl)-1-(3-(4-Methoxyphenyl)propyl)piperidine h
4-(3,3-diphenylpropyl)-1-(3-(4-methoxyphenyl)propyl)piperidine hydrochloride
4-((Benzhydryloxy)Methyl)-1-(3-(4-Methoxyphenyl)propyl)piperidine hydrochloride
4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride
4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine monohydrochloride | [Molecular Formula]
C29H35NO2.HCl | [MDL Number]
MFCD16875438 | [MOL File]
136647-02-4.mol | [Molecular Weight]
466 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: >10mg/mL | [form ]
solid | [color ]
white to off-white | [InChI]
1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H | [InChIKey]
ZZSQARULZYQMIG-UHFFFAOYSA-N | [SMILES]
Cl.COc1ccc(CCCN2CCC(CC2)COC(c3ccccc3)c4ccccc4)cc1 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,N | [Risk Statements ]
36-50/53 | [Safety Statements ]
26-60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
UK 78282 Hydrochloride is used in the synthetic preparation of N-arylalkylpiperidine and -pyrrolidine derivatives for treating irritable bowel syndrome. | [Biological Activity]
UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cellsand Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In additionKv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activationcontributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefitand they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desiredas there are few if any currently available. UK-78282 is valuable for immune system studieswhere the absence of Kv1.4 makes it functionally selective for Kv1.3and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function. | [storage]
Store at -20°C |
|
| Company Name: |
SynAsst Chemical.
|
| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
|