| Identification | Back Directory | [Name]
ALPHA-DEFENSIN-3 (HUMAN) | [CAS]
136661-76-2 | [Synonyms]
DEF3
DEFA3
HNP-3
Defensin HNP-3
Defensin, alpha 3
Neutrophil defensin 3
DEFENSIN HNP-3 (HUMAN)
ALPHA-DEFENSIN-3 (HUMAN)
HUMAN NEUTROPHIL PEPTIDE-3
HuMan Neutrophil Peptide-3, HNP-3
HuMan Neutrophil Peptide-1, HNP-1
ANTI-DEFA3(C-TERMINAL) antibody produced in rabbit
Defensin HNP-1 (huMan)
HuMan Neutrophil Peptide-1, HNP-1
Defensin HNP-3 (huMan)
HuMan Neutrophil Peptide-3, HNP-3
ASP-CYS-TYR-CYS-ARG-ILE-PRO-ALA-CYS-ILE-ALA-GLY-GLU-ARG-ARG-TYR-GLY-THR-CYS-ILE-TYR-GLN-GLY-ARG-LEU-TRP-ALA-PHE-CYS-CYS
H-Asp-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH
H-Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH
H-ASP-CYS-TYR-CYS-ARG-ILE-PRO-ALA-CYS-ILE-ALA-GLY-GLU-ARG-ARG-TYR-GLY-THR-CYS-ILE-TYR-GLN-GLY-ARG-LEU-TRP-ALA-PHE-CYS-CYS-OH, (DISULFIDE BONDS BETWEEN CYS2 AND CYS30/CYS4 AND CYS19/ CYS9 AND CYS29) | [Molecular Formula]
C151H222N44O40S6 | [MDL Number]
MFCD00236951 | [MOL File]
136661-76-2.mol | [Molecular Weight]
3486.04 |
| Chemical Properties | Back Directory | [density ]
1.54±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [Sequence]
H-Asp-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys (Disulfide bonds between Cys2 and Cys3?/Cys? and Cys1?/Cys? and Cys2?) |
| Hazard Information | Back Directory | [Uses]
Defensin HNP-3 human is a cytotoxic antibiotic peptide known as "defensin". Defensin HNP-3 human has inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. Defensin HNP-3 human is initially synthesized as the 94 amino acids preproHNP(1-94), which is hydrolyzed to proHNP(20-94) and converted to mature HNP(65-94) after the removal of anion precursors[1][2]. | [References]
[1] Valore EV, et al. Intramolecular inhibition of human defensin HNP-1 by its propiece. J Clin Invest. 1996 Apr 1;97(7):1624-9. DOI:10.1172/JCI118588
[2] Ganz T, et al. Defensins. Natural peptide antibiotics of human neutrophils[J]. The Journal of clinical investigation, 1985, 76(4): 1427-1435. |
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