| Chemical Properties | Back Directory | [density ]
1.53±0.1 g/cm3(Predicted) | [Sequence]
H-Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH (Disulfide bonds between Cys2 and Cys3?/Cys? and Cys1?/Cys? and Cys2?) |
| Hazard Information | Back Directory | [Uses]
Defensin HNP-1 human is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human exhibits broad antimicrobial and anti-leishmanial activities[1][2]. | [IC 50]
Leishmania | [References]
[1] Dabirian S, et, al. Human neutrophil peptide-1 (HNP-1): a new anti-leishmanial drug candidate. PLoS Negl Trop Dis. 2013 Oct 17;7(10):e2491. DOI:10.1371/journal.pntd.0002491
[2] Higazi M, et, al. Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis. PLoS One. 2020 Apr 17;15(4):e0231582. DOI:10.1371/journal.pone.0231582 |
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