| Identification | Back Directory | [Name]
H-SER-VAL-SER-GLU-ILE-GLN-LEU-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-ASN-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE-VAL-ALA-LEU-OH | [CAS]
136799-54-7 | [Synonyms]
Human PTH(1-37)
PTH (1-37) (HUMAN)
PARATHYRIN (1-37) (HUMAN)
PARATHYROID HORMONE (1-37) (HUMAN)
Parathyrin (1-37) (huMan), Parathyroid HorMone (1-37) (huMan)
H-SER-VAL-SER-GLU-ILE-GLN-LEU-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-ASN-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE-VAL-ALA-LEU-OH | [MDL Number]
MFCD00243099 |
| Chemical Properties | Back Directory | [form ]
Solid | [color ]
White to off-white | [Sequence]
Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-Val-Ala-Leu |
| Hazard Information | Back Directory | [Uses]
pTH (1-37) (human) is a fragment of parathyroid hormone (PTH). pTH (1-37) (human) induces the cAMP formation and increases alkaline phosphatase activity. pTH (1-37) (human) increases growth, bone calcium content, and bone mineral density (BMD) in uremic animals. pTH (1-37) (human) has the potential for the research of osteoporosis[1][2][3]. | [References]
[1] Tsai JA, et al. Parathyroid hormone-related protein (1-37) induces cAMP response in human osteoblast-like cells. Calcif Tissue Int. 1998 Mar;62(3):250-4. DOI:10.1007/s002239900425
[2] Schmitt CP, et al. Intermittent administration of parathyroid hormone (1-37) improves growth and bone mineral density in uremic rats. Kidney Int. 2000 Apr;57(4):1484-92. DOI:10.1046/j.1523-1755.2000.00993.x
[3] Stephan S, et al. Intermittent administration of the circulating form of human parathyroid hormone (hPTH-1-37) prevents bone loss in ovariectomized rats. Eur J Med Res. 2007 Jan 31;12(1):13-20. PMID:17363353 |
|
|