| Identification | Back Directory | [Name]
AZ-33 | [CAS]
1370290-34-8 | [Synonyms]
AZ-33
AZ-33(AZ33)
LDHA Inhibitor
AZ-33;AZ33;AZ 33
2-(4-(4-((3-((2-methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonic acid
2-[[4-[4-[[3-[(2-Methyl-6-benzothiazolyl)amino]-3-oxopropyl]amino]-4-oxobutyl]phenyl]methyl]propanedioic acid
Propanedioic acid, 2-[[4-[4-[[3-[(2-methyl-6-benzothiazolyl)amino]-3-oxopropyl]amino]-4-oxobutyl]phenyl]methyl]- | [Molecular Formula]
C25H27N3O6S | [MDL Number]
MFCD29913759 | [MOL File]
1370290-34-8.mol | [Molecular Weight]
497.56 |
| Chemical Properties | Back Directory | [Boiling point ]
843.9±65.0 °C(Predicted) | [density ]
1.381±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMF: 30mg/mL; DMSO: 30mg/mL; Ethanol: 2mg/mL; PBS (pH 7.2): slight | [form ]
A crystalline solid | [pka]
3.21±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AZ-33 is a selective lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 0.5 μM and a Kd of 0.093 μM[1]. | [References]
[1] Ward RA,et al. Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation. J Med Chem. 2012 Apr 12;55(7):3285-306. DOI:10.1021/jm201734r |
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