| Identification | Back Directory | [Name]
Cilliobrevin D | [CAS]
1370554-01-0 | [Synonyms]
Cilliobrevin D
Cytoplasmic Dynein Inhibitor, Ciliobrevin D
Benzenepropanenitrile, 2,4-dichloro-α-(7-chloro-3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo- | [Molecular Formula]
C17H8Cl3N3O2 | [MDL Number]
MFCD32671360 | [MOL File]
1370554-01-0.mol | [Molecular Weight]
392.62 |
| Chemical Properties | Back Directory | [Boiling point ]
591.8±50.0 °C(Predicted) | [density ]
1.537±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5 mg/mL (12.73 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
5.99±0.20(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C17H8Cl3N3O2/c18-8-1-3-10(13(20)5-8)15(24)12(7-21)16-22-14-6-9(19)2-4-11(14)17(25)23-16/h1-6,22H,(H,23,25) | [InChIKey]
JKKSCGHDRHRWOQ-UHFFFAOYSA-N | [SMILES]
C(=C1NC(=O)C2=CC=C(Cl)C=C2N1)(C#N)C(C1C=CC(Cl)=CC=1Cl)=O |
| Hazard Information | Back Directory | [Uses]
Ciliobrevin D is an inhibitor of the AAA+ ATPase motor cytoplasmic dynein. | [in vivo]
Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D in the testis in vivo perturbs spermatogenesis. Knockdown of Dync1h1 or the use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity. F-actin disorganization in the seminiferous epithelium following Dync1h1 knockdown or dynein 1 inactivation by Ciliobrevin D is mediated by changes in the spatiotemporal expression of actin regulatory proteins Arp3 and Eps8[3]. | [storage]
Store at -20°C |
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