| Identification | Back Directory | [Name]
2-(2-decenoylamino)ethyl-2-(cyclohexylethyl)sulfide | [CAS]
137089-36-2 | [Synonyms]
2-(2-decenoylamino)ethyl-2-(cyclohexylethyl)sulfide
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
2-Decenamide, N-[2-[(2-cyclohexylethyl)thio]ethyl]-, (E)- (9CI) | [Molecular Formula]
C20H37NOS | [MDL Number]
MFCD00884830 | [MOL File]
137089-36-2.mol | [Molecular Weight]
339.58 |
| Chemical Properties | Back Directory | [Boiling point ]
503.3±42.0 °C(Predicted) | [density ]
0.954±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
14.50±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
(E)-N-[2-[(2-Cyclohexylethyl)thio]ethyl]-2-decenamide, can be used as an anti-ulcerogenic. It inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress. | [in vivo]
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (compd.III-1α, 100 mg/kg, p.o.) maintains the relative content of Fr.I hexose, lipid peroxide and phospholipase A2 (PLA2) in normal level in ulcerated rats induced by water immersed restrained stress via dosing twice a day for 3 day (b.i.d. for 3 d). 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (100 mg/kg, p.o.) reduces the hexosamine content equally with the control group 4 h after the stress loading, and then markedly increases 7 h after stress loading. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (25 mg/kg, p.o.) blocks the reduction of prostaglandin E2 (PGE2) and PGI2 in early phase and accelerates the increase of PGE2 and PGI2 in the late phase of the stress. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (25 mg/kg, p.o.) also significantly accelerates the cell proliferation in fundic glands in gastric mucosa of mice[1]. | [IC 50]
PGI2; PLA2 |
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