| Identification | More | [Name]
Ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate | [CAS]
137156-41-3 | [Synonyms]
1-Hydroxy-1H-1,2,3-triazole-5-carboxylic acid ethyl ester
Ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate
HOCt
HOCT [Ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate] | [Molecular Formula]
C5H7N3O3 | [MDL Number]
29339900 | [Molecular Weight]
157.13 | [MOL File]
137156-41-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
105 °C | [Boiling point ]
339.1±34.0 °C(Predicted) | [density ]
1.49 | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
6.10±0.58(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C5H7N3O3/c1-2-11-5(9)4-3-8(10)7-6-4/h3,10H,2H2,1H3 | [InChIKey]
FIRHQRGFVOSDDY-UHFFFAOYSA-N | [SMILES]
N1(O)C=C(C(OCC)=O)N=N1 | [CAS DataBase Reference]
137156-41-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate (HOCt) is an optimal coupling reagent used for solid phase peptide synthesis in Fmoc chemistry. It is used in combination with carbodiimide reagents, has very high coupling efficiency, and does not absorb at 302nm, thus allowing real-time monitoring of each coupling cycle in SPPS. | [References]
[1] Jiang, L., Davison, A., Tennant, G., & Ramage, R. (1998). Synthesis and application of a novel coupling reagent, ethyl 1-hydroxy-1H -1,2,3-triazole-4-carboxylate. Tetrahedron, 54 47, Pages 14233-14254. https://doi.org/10.1016/S0040-4020(98)00876-X
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