| Identification | Back Directory | [Name]
LAS 31180 | [CAS]
137338-43-3 | [Synonyms]
LAS 31180
Methanesulfonamide, N-(1,4-dihydro-1-methyl-4-oxo-3-quinolinyl)- | [Molecular Formula]
C11H12N2O3S | [MDL Number]
MFCD00905994 | [MOL File]
137338-43-3.mol | [Molecular Weight]
252.29 |
| Chemical Properties | Back Directory | [Boiling point ]
386.7±52.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
5.70±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties. | [in vivo]
In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1]. | [storage]
Store at -20°C | [References]
[1] Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.. . . . . DOI:10.1055/s-0031-1300321
[2] Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6. |
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