137338-43-3
137338-43-3 结构式
物理化学性质
沸点386.7±52.0 °C(Predicted)
密度1.42±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)5.70±0.20(Predicted)
常见问题列表
生物活性
LAS-31180 是一种 phosphodiesterase 3 的抑制剂，能够增强肌肉收缩和血管舒张。体外研究
LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC 50 of 1.2 mumol/L) and in isolated guinea-pig working hearts.
体内研究
In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure.