| Identification | Back Directory | [Name]
Ethanone, 2-(4-hydroxyphenyl)-1-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)- | [CAS]
1373764-75-0 | [Synonyms]
YH306
YH-306
T24642
YH 306
Ethanone, 2-(4-hydroxyphenyl)-1-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)- | [Molecular Formula]
C19H18N2O2 | [MOL File]
1373764-75-0.mol | [Molecular Weight]
306.36 |
| Chemical Properties | Back Directory | [Boiling point ]
600.8±55.0 °C(Predicted) | [density ]
1.331±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 20 mg/mL (65.28 mM; ultrasonic and adjust pH to 1 with HCl) | [form ]
Solid | [pka]
9.90±0.15(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Uses]
YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization[1]. | [Biological Activity]
YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization[1]. | [IC 50]
PI3K; MMP2; MMP9 | [storage]
4°C, protect from light | [References]
[1]. Dai F, et al. A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. J Cell Mol Med. 2015 Feb;19(2):383-95. |
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