| Identification | Back Directory | [Name]
Azido-PEG1-t-butyl ester | [CAS]
1374658-85-1 | [Synonyms]
Azido-PEG1-Boc
CAS_1374658-85-1
Azido-PEG1-t-butyl ester
tert-Butyl 3-(2-azidoethoxy)propanoate
Azido-PEG1-t-butyl ester,N3-PEG1-t-butyl ester,Azido-PEG1-Boc | [Molecular Formula]
C9H17N3O3 | [MDL Number]
MFCD22201524 | [MOL File]
1374658-85-1.mol | [Molecular Weight]
215.25 |
| Hazard Information | Back Directory | [Description]
Azido-PEG1-t-butyl ester is a azide containing molecules. it can react with alkyne, such as BCN, DBCO via Click Chemistry to yield a stable triazole linkage. | [Uses]
Azido-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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