| Identification | Back Directory | [Name]
2-Azidoethanol | [CAS]
1517-05-1 | [Synonyms]
1517-05-1
Ccris 4996
Azidoethanol
CAS_1517-05-1
2-Azidoethanol
2-azidoethan-1-ol
Ethanol, 2-azido-
2-Azido-1-ethanol
Azido-PEG1-alcohol
Ethanol,2-diazenyl-
2-Hydroxyethyl azide
2-Azido-ethanol,Azido-PEG1-alcohol | [Molecular Formula]
C2H5N3O | [MDL Number]
MFCD01940545 | [MOL File]
1517-05-1.mol | [Molecular Weight]
87.0806 |
| Chemical Properties | Back Directory | [Boiling point ]
77℃ (24 Torr) | [density ]
1.1460 | [refractive index ]
1.4264 (estimate) | [storage temp. ]
2-8°C, sealed storage, away from moisture | [solubility ]
Chloroform (Soluble), DMSO (Sparingly), Methanol (Soluble) | [form ]
Oil | [color ]
Colourless | [Stability:]
Light Sensitive | [InChI]
InChI=1S/C2H5N3O/c3-5-4-1-2-6/h6H,1-2H2 | [InChIKey]
BSULWPSUVMOMAN-UHFFFAOYSA-N | [SMILES]
C(CO)N=[N+]=[N-] |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless Slightly Yellow Clear Liquid. | [Uses]
2-Azidoethanol is used as a reagent in the glycosylation of mono- or polysaccharides. 2-Azidoethanol is also used as a 2’-deoxy-ethynyluridine (EdU) blocker in nuclear DNA, preventing cross reactivity with other antibodies in order to better study its related pathways in the body. | [Preparation]
2-Azidoethanol synthesis: Sodium azide (14.6 g, 224 mmol, 1.5 eq.) was added portion wise to a stirred mixture of 2- chloroethanol (12.0 g, 149 mmol, 1 eq.) in H2O (80 mL) at 0°C. The reaction mixture was slowly warmed up to room temperature and stirred for another 4 h. Additional sodium azide (9.71 g, 149 mmol, 1 eq.) was added and the solution was heated under reflux at 80°C overnight. After completion, the mixture was extracted with Et2O (3×50 mL) and the combined organic phases were washed with Brine (1× 10 mL) and dried over MgSO4. The solvent was removed in vacuo to yield a colorless oil (10.57 g, 121.4 mmol, 81%).
1 H NMR (400 MHz, CDCl3, ppm): δ=3.77 (q, 2H, CH2 OH), 3.43 (t, 2H, CH2 N3), 2.16 (s, 1H, OH). 13C NMR (101 MHz, CDCl3, ppm): δ=61.6 (CH2 OH), 53.7 (CH2 N3). 14N NMR (CDCl3, ppm): δ= 134 (Nβ), 171 (Nγ), 319 (Nα). C2H5N3O (87.08 gmol 1 ) calcd. N 48.25, C 27.59, H 5.79%; found IS: >40 J. FS: >360 N. | [IC 50]
PEGs |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
T&W GROUP
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| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
| Company Name: |
NovoChemy Ltd.
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| Telephone: |
86-(0)21-31261262 373522135 |
| Website: |
www.novochemy.com |
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