| Identification | Back Directory | [Name]
Di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone | [CAS]
1382469-39-7 | [Synonyms]
DpC >=98% (HPLC)
Di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone
N-Cyclohexyl-2-(di-2-pyridinylmethylene)-N-methylhydrazinecarbothioamide
N-Cyclohexyl-2-(di(pyridin-2-yl)methylene)-N-methylhydrazinecarbothioamide
Hydrazinecarbothioamide, N-cyclohexyl-2-(di-2-pyridinylmethylene)-N-methyl- | [Molecular Formula]
C19H23N5S | [MDL Number]
MFCD22666593 | [MOL File]
1382469-39-7.mol | [Molecular Weight]
353.48 |
| Chemical Properties | Back Directory | [Boiling point ]
510.7±48.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble5mg/mL (clear solution) | [form ]
powder | [pka]
10.22±0.70(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
DpC is an anti-tumor agent. DpC inhibits cancer cell proliferation (IC50: 0.007-0.096 μM). DpC synergizes with multiple anti-cancer therapeutics[1]. | [Biochem/physiol Actions]
DpC is an iron-chelating agent. | [References]
[1] Dharmasivam M, et al. The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature- and energy-dependent uptake by tumor cells. Biochim Biophys Acta Gen Subj. 2022 Aug;1866(8):130152. DOI:10.1016/j.bbagen.2022.130152 |
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