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138564-60-0

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138564-60-0 Structure

138564-60-0 Structure
IdentificationMore
[Name]

4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride
[CAS]

138564-60-0
[Synonyms]

4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride
4-AMINO-2-METHYL-10H-THIENO[2,3-B]1,5BENZODIAZEPINE HCL
4-AMINO-2-METHYL-10H-THIENO [2,3-B] [1,5] BENZODIAZEPINE HYDROCHLORIDE
TIMTEC-BB SBB001030
4-Amino-2-Methyl-10H-[2,3-b][1,5]Benzodiazepine HCL
4-amino-2-methyl-10H-Thieno [2,3-b] [1,5] Benzodiazepine Hydrochloride(Intermediate for Olanzapine)
4-AMINO-2-METHYL-10H-THIONE[2,3-B][1,5]BENZODIAZEPINE HCL
4-Amino-2-Methyl-10h-Thieno[2,3-B][1,5]-Benzodiazapine, Hydrochloride
4-AMINO-2-METHYL-10H-THIENO[2,3-B][1,5] BENZODIAZAPINE HCL
4-Amino-2-Methyl-1OH-Thiene[2,3-B][1,5]Benzodiazepine Hydrochloride
4-Amino-2-Methyl-10H-Thieno[2,3-B][1,5]BenxodiazepineHcl
Intermediates of Olanzapine
4-Amino-2-methyl-10H-thieno[2,3-β][1,5]-benzodiazapine, Hydrochloride
[EINECS(EC#)]

604-085-0
[Molecular Formula]

C12H12ClN3S
[MDL Number]

MFCD03085920
[Molecular Weight]

265.76
[MOL File]

138564-60-0.mol
Questions And AnswerBack Directory
[Synthesis]

In a 500 mL round-bottom flask equipped with a mechanical stirrer and thermometer, 10.0 g (0.0386 mol) of 5-methyl-2-((2-nitrobenzene)amino)thiophene-3-carboxynitrile (1) and 100 mL of ethanol were added. Then 7.4 g (0.062 mol) of tin powder and 84 mL of 4M hydrochloric acid were added, and the mixture was stirred at 50 °C for 0.5 h. The temperature of the reaction mixture was raised to 85 °C, and stirring was continued for 4 h. The mixture was then cooled to 25 °C and stirred for another 8 h, which resulted in the precipitation of a solid. The precipitated crystals were collected, washed with 20 mL of ethanol, and dried under vacuum. 9.8 g (96%) of 2-methyl-2-(nitrobenzene) ...

Synthetic route of 4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride

Chemical PropertiesBack Directory
[Appearance]

Yellow Crystaline solid
[Melting point ]

283-285°C
[storage temp. ]

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
[solubility ]

DMSO (Slightly), Methanol (Sparingly, Sonicated)
[form ]

Solid
[color ]

Yellow to Dark Beige
[InChI]

InChI=1S/C12H11N3S.ClH/c1-7-6-8-11(13)14-9-4-2-3-5-10(9)15-12(8)16-7;/h2-6,15H,1H3,(H2,13,14);1H
[InChIKey]

FDWMAKNNNPSUTL-UHFFFAOYSA-N
[SMILES]

C12SC(C)=CC=1C(N)=NC1=CC=CC=C1N2.Cl
[CAS DataBase Reference]

138564-60-0(CAS DataBase Reference)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
[REACH Registrations]

Active
[HS Code ]

2933998090
Hazard InformationBack Directory
[Chemical Properties]

Yellow Crystaline solid
[Uses]

Intermediate in the preparation of Olanzapine (O253750).
Spectrum DetailBack Directory
[Spectrum Detail]

4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride(138564-60-0)1HNMR
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