| Identification | Back Directory | [Name]
CL 316243 | [CAS]
138908-40-4 | [Synonyms]
CL 316243
CL-316243 sodium
CL 316,243 hydrate
COLLAGEN FROM HUMAN LUNG
CL 316243 disodium
(CL316243 disodium)
inhibit,Adrenergic Receptor,CL 316243,Inhibitor,Beta Receptor,CL-316243,CL316243
Disodium 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate
Disodium 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate hydrate | [Molecular Formula]
C20H18ClNO7.2Na | [MDL Number]
MFCD00907153 | [MOL File]
138908-40-4.mol | [Molecular Weight]
465.795 |
| Chemical Properties | Back Directory | [storage temp. ]
room temp | [solubility ]
H2O: >10 mg/mL
| [form ]
solid
| [color ]
white
| [Water Solubility ]
Soluble to 100 mM in water | [InChIKey]
BFEWLXURNRQQLY-BELDDISZSA-L | [SMILES]
O.[Na+].[Na+].C[C@H](Cc1ccc2OC(Oc2c1)(C([O-])=O)C([O-])=O)NC[C@H](O)c3cccc(Cl)c3 |
| Hazard Information | Back Directory | [Hazard]
A poison.
| [Uses]
CL 316,243 hydrate has been used:
- as a β-agonists to inject mice and study its effect on the expression of mammalian major facilitator superfamily domain-containing protein (Mfsd2a)
- as an adrenergic agonist to stimulate adrenergic response in order to study the metabolic activity of brown, beige and white adipose tissues in mice
- as a β3-adrenergic agonist to inject mice for in vivo lipolytic challenge
| [Uses]
CL 316243 Disodium Salt is a potent and highly selective β3-adrenoceptor agonist. | [Biochem/physiol Actions]
β Adrenoceptor is expressed in a number of tissues such as heart, adipose tissue, colon and other tissues. It is associated with many different biological functions. β Adrenoceptor fills in as an objective for treating type 2 diabetes, heart failure, cachexia, obesity, metabolic disorder, issues related with bladder, colon and malignant tumor growth. Depression and anxiety can also be treated via β adrenoceptor. CL 316,243 is known to have antidiabetic action via β adrenoceptor. It is a potent stimulator of lipolysis. It also activates β3- adrenoceptors on neurons in hypothalamic areas that are important in the central regulation of appetite. | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
|