| Identification | Back Directory | [Name]
6-(6-(4-hydroxypiperidinyl)hexyloxy)-3-methylflavone HCl | [CAS]
139652-86-1 | [Synonyms]
Sigma-LIGAND-1 hydrochloride
6-(6-(4-hydroxypiperidinyl)hexyloxy)-3-methylflavone HCl | [Molecular Formula]
C27H34ClNO4 | [MOL File]
139652-86-1.mol | [Molecular Weight]
472.02 |
| Hazard Information | Back Directory | [Uses]
Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 hydrochloride has a Ki of 4000 nM at the dopamine D2 receptor[1]. | [in vivo]
Administration of Sigma-LIGAND-1 hydrochloride reverseS amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 hydrochloride and its structural analogues have the potential antipsychotic activity[1]. | [References]
[1] Erickson RH, et al. (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem. 1992 May 1;35(9):1526-35. DOI:10.1021/jm00087a005 |
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