| Identification | Back Directory | [Name]
1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE | [CAS]
154130-99-1 | [Synonyms]
PD 144418
PD 144418 OXALATE
Pyridine,1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propyl-
1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE | [Molecular Formula]
C18H22N2O | [MDL Number]
MFCD00924135 | [MOL File]
154130-99-1.mol | [Molecular Weight]
282.38 |
| Chemical Properties | Back Directory | [Boiling point ]
453.2±45.0 °C(Predicted) | [density ]
1.067±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
<18.62mg/ml in DMSO | [form ]
solid | [pka]
8.10±0.40(Predicted) | [color ]
Off-white |
| Hazard Information | Back Directory | [Uses]
PD 144418 is high affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). PD 144418 displays no significant activity at a wide range of other receptors, ion channels and enzymes. PD 144418 antagonizes mescaline-induced scratching in mice following i.p. administration. | [Biological Activity]
High affinity, selective σ 1 ligand (K i values are 0.08 and 1377 nM for σ 1 and σ 2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. | [in vivo]
PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) treatment antagonizes Mescaline-induced scratching at doses that did not alter spontaneous motor activity, with PD 144418 showing ED50 values of 7.0 mg/kg i.p.[1]. | Animal Model: | Male CD-1 mice induced with Mescaline[1] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Antagonized mescaline-induced scratching at doses that did not alter spontaneous motor activity.
|
| [storage]
Desiccate at RT |
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