| Identification | Back Directory | [Name]
4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid | [CAS]
1402612-64-9 | [Synonyms]
KT203
KT203 >=98% (HPLC)
4′-(1-(2-benzylpiperidine-1-carbonyl)-1H-1,2,3-triazol-4-yl)-[1,1′-biphenyl]-3-carboxylic acid
4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid
[1,1'-Biphenyl]-3-carboxylic acid, 4'-[1-[[2-(phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]- | [Molecular Formula]
C28H26N4O3 | [MDL Number]
MFCD28118915 | [MOL File]
1402612-64-9.mol | [Molecular Weight]
466.53 |
| Chemical Properties | Back Directory | [Boiling point ]
724.3±62.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≤10mg/ml in DMSO;10mg/ml in dimethyl formamide | [form ]
crystalline solid | [pka]
4.02±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
KT203 is a potent and selective inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.31 nM in Neuro2A cells[1]. | [Biological Activity]
kt203 is an abhd6 inhibitor.abhd6, a unique and highly conserved enzyme in mammals, is prominently expressed in brain, liver, kidney, and brown adipose tissue based on global gene expression analysis and activitybased protein profiling (abpp). | [in vitro]
the in-vitro potency of kt203 was studied and it was found that kt203 was able to potently inhibit abhd6 as measured by gelbased competitive abpp and 2-ag hydrolysis assays. moreover, the in-situ potency was then measured by treating neuro2a cells with varying concentrations of kt203 for 4 h and the results showed that kt203 inhibited abhd6 with ic50 values in the subnanomolar range [1]. | [in vivo]
in a previous animal study, mice were treated intraperitoneally with kt203 at various doses (0.1-1 mg/kg) for 4 h. results showed that kt203 had near-complete blockade of abhd6 in the liver at the highest dose tested. at lower doses, kt203 showed about 80% inhibition of abhd6 in the liver. notably, kt203 exhibited impressive selectivity in the mouse liver even at higher doses, showing little cross-reactivity against the numerous carboxylesterase enzymes that are common off-targets of mechanism-based sh inhibitors in rodents. in addition, kt203 showed good selectivity against other brain and liver shs as judged by gelbased abpp, suggesting a single major off-target, carboxylesterase-1 (ces1) [1]. | [IC 50]
< 5 nm | [References]
[1] hsu kl, tsuboi k, chang jw, whitby lr, speers ae, pugh h, cravatt bf. discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (abhd6). j med chem. 2013 nov 14;56(21):8270-9. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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