| Identification | Back Directory | [Name]
CAY10499 | [CAS]
359714-55-9 | [Synonyms]
CAY10499
CAY10499 Exclusive
QTENHWTVRQKWRI-UHFFFAOYSA-N | [Molecular Formula]
C18H17N3O5 | [MDL Number]
MFCD12912259 | [MOL File]
359714-55-9.mol | [Molecular Weight]
355.34 |
| Chemical Properties | Back Directory | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
crystalline solid | [pka]
13.31±0.70(Predicted) | [color ]
Off-white to yellow | [InChI]
InChI=1S/C18H17N3O5/c1-12-10-14(21-18(23)26-17(20-21)24-2)8-9-15(12)19-16(22)25-11-13-6-4-3-5-7-13/h3-10H,11H2,1-2H3,(H,19,22) | [InChIKey]
QTENHWTVRQKWRI-UHFFFAOYSA-N | [SMILES]
C(OCC1=CC=CC=C1)(=O)NC1=CC=C(N2N=C(OC)OC2=O)C=C1C |
| Hazard Information | Back Directory | [Description]
CAY10499 is a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively).1,2 It also inhibits ATGL, DAGLa, ABHD6, and CES1 by 95, 60, 90, and 95%, respectively, when used at a concentration of 5 mM.3 CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 μM, respectively).2 In vivo, CAY10499 reduces FRUC diet- and AIN-93M diet-induced increases in cytosolic lipase activity in rats.4 | [Uses]
CAY10499 (MAGL-IN-5) is a non-selective lipase inhibitor with IC50 values of 144 nM and 14 nM for monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), respectively. Additionally, CAY10499 exhibits anti-inflammatory and antiviral activities[1][2][3][4]. | [Definition]
ChEBI: CAY10499 is a carbamate ester. | [in vivo]
CAY10499 (intraperitoneal injection; 0.01-10 mg/kg; twice daily; 4 days) exhibits protective and antiviral activities in a mouse model infected with IAV, and can improve the survival rate of mice[2]. | [References]
[1] muccioli g g, labar g, lambert d m. cay10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious mgl assay[j]. chembiochem, 2008, 9(16): 2704-2710.
[2] ben ali y, muller g, petry s, et al. kinetic characterization and specific inhibition of hormone sensitive lipase[c]//chemistry and physics of lipids. elsevier house, brookvale plaza, east park shannon, co, clare, 00000, ireland: elsevier ireland ltd, 2005, 136(2): 155-155.
[3] kraemer f b, shen w j. hormone-sensitive lipase control of intracellular tri-(di-) acylglycerol and cholesteryl ester hydrolysis[j]. journal of lipid research, 2002, 43(10): 1585-1594. |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|