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1402931-72-9

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1402931-72-9 Structure

1402931-72-9 Structure
IdentificationBack Directory
[Name]

eIF4A3-IN-10
[CAS]

1402931-72-9
[Synonyms]

eIF4A3-IN-10
[Molecular Formula]

C29H29NO8
[MOL File]

1402931-72-9.mol
[Molecular Weight]

519.54
Chemical PropertiesBack Directory
[Boiling point ]

636.882±55.00 °C(Press: 760.00 Torr)(predicted)
[density ]

1.361±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

11.587±0.70(predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

eIF4A3-IN-10 (compound 58) is a silvestrol (HY-13251) analogue. eIF4A3-IN-10 interferes the assembling of eIF4F translation complex with EC50s of 35 and 100 nM for myc-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-10 can be used for the research of human cancer pathogenesis[1].
[References]

[1] Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. DOI:10.1021/jm3011542
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