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1403894-72-3

1403894-72-3 Structure

1403894-72-3 Structure
IdentificationBack Directory
[Name]

1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-
[CAS]

1403894-72-3
[Synonyms]

IRL790
Mesdopetam
1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-
[Molecular Formula]

C12H18FNO3S
[MOL File]

1403894-72-3.mol
[Molecular Weight]

275.34
Chemical PropertiesBack Directory
[Boiling point ]

428.5±45.0 °C(Predicted)
[density ]

1.175±0.06 g/cm3(Predicted)
[pka]

9.26±0.19(Predicted)
Hazard InformationBack Directory
[Uses]

Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease[1][2].
[in vivo]

Mesdopetam (IRL790) (3.7, 11, 33, or 100 μmol/kg) dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80[1].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:3.7, 11, 33, or 100 μmol/kg (synthesized in-house as HCl salt, was dissolved in physiologic saline (0.9% w/v NaCl)
Administration:s.c. was administered subcutaneously 4 min before the start of recording
Result:Dose-dependently inhibited the behavioral activation following pretreatment with D-amphetamine or MK-801.
[IC 50]

D3 Receptor
[References]

[1] Waters S, et al. Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. J Pharmacol Exp Ther. DOI:10.1124/jpet.119.264226
[2] Becanovic K, et al. Effects of a Novel Psychomotor Stabilizer, IRL790, on Biochemical Measures of Synaptic Markers and Neurotransmission. J Pharmacol Exp Ther. 2020;374(1):126-133. DOI:10.1124/jpet.119.264754
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