Identification | Back Directory | [Name]
1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]- | [CAS]
1403894-72-3 | [Synonyms]
IRL790 Mesdopetam 1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]- | [Molecular Formula]
C12H18FNO3S | [MOL File]
1403894-72-3.mol | [Molecular Weight]
275.34 |
Hazard Information | Back Directory | [Uses]
Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease[1][2]. | [in vivo]
Mesdopetam (IRL790) (3.7, 11, 33, or 100 μmol/kg) dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80[1]. Animal Model: | Male Sprague-Dawley rats[1] | Dosage: | 3.7, 11, 33, or 100 μmol/kg (synthesized in-house as HCl salt, was dissolved in physiologic saline (0.9% w/v NaCl) | Administration: | s.c. was administered subcutaneously 4 min before the start of recording | Result: | Dose-dependently inhibited the behavioral activation following pretreatment with D-amphetamine or MK-801.
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D3 Receptor | [References]
[1] Waters S, et al. Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. J Pharmacol Exp Ther. DOI:10.1124/jpet.119.264226 [2] Becanovic K, et al. Effects of a Novel Psychomotor Stabilizer, IRL790, on Biochemical Measures of Synaptic Markers and Neurotransmission. J Pharmacol Exp Ther. 2020;374(1):126-133. DOI:10.1124/jpet.119.264754 |
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