| Identification | More | [Name]
R-(-)-Apomorphine | [CAS]
41372-20-7 | [Synonyms]
6a-beta-aporphine-10,11-diol
APOMORPHINE HYDROCHLORIDE, HEMIHYDRATE
(r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo[de,g]quinoline-10,11-diol
r-(-)-apomorphine
R-(-)-APOMORPHINE HYDROCHLORIDE HEMIHYDRATE
4H-Dibenzode,gquinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (2:1), (6aR)-
APOMORPHINEHCLHEMIHYDRATE
APOMORPHINEHYDROCHLORIDE,HEMIHYDRATE,USP
Apomophine hydrochloride
R-(-)-Apomorphine hemihydrate hydrochloride
Apomorphine hydrochloride R-(-)- | [EINECS(EC#)]
627-402-4 | [Molecular Formula]
C17H17NO2 | [MDL Number]
MFCD00150904 | [Molecular Weight]
267.32 | [MOL File]
41372-20-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
285-287 °C(lit.) | [alpha ]
-48 º (c=1, H2O) | [storage temp. ]
Refrigerator | [solubility ]
H2O: ~10 mg/mL, clear, yellow-green
| [form ]
calcined
| [color ]
white to gray
| [PH]
pH(10g/l, 25℃) : 4.0～5.0 | [Water Solubility ]
H2O: ~10mg/mL, clear, yellow-green | [Merck ]
13,751 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week. | [InChI]
1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1 | [InChIKey]
CXWQXGNFZLHLHQ-DPFCLETOSA-N | [SMILES]
Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68 | [CAS DataBase Reference]
41372-20-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301 | [Precautionary statements ]
P301+P330+P331+P310 | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [HS Code ]
2933997000 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
| Hazard Information | Back Directory | [Description]
Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse mode1,2 In clinical use for Parkinson’s disease.4,5 | [Chemical Properties]
Off-White Solid | [Uses]
R-(?)-Apomorphine hydrochloride hemihydrate is a nonselective dopamine agonist with anti-Parkinsonian and neuroprotective effects in vivo. | [Uses]
Dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian. | [Uses]
emetic, antiparkinsonian, erextile dysfunction therapy | [Brand name]
Apokyn
(Vernalis). | [Purification Methods]
Crystallise the salt from H2O (hemihydrate) and from EtOH. Crystals turn green on exposure to light. (see previous entry). NARCOTIC. | [References]
1) Merck Index 14:746
2) Millan et al. (2002), Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes; J. Pharmacol. Exp. Therap., 303 791
3) Grunblatt et al. (1999), Apomorphine protects against MPTP-induced neurotoxicity in mice.; Mov. Discord, 14 612
4) Auffret et al. (2017), Apomorphine pump in advanced Parkinson’s disease: Effects on motor and nonmotor symptoms with brain metabolism correlations; J. Neurol. Sci, 372 279
5) Jenner and Katzenschlager (2016), Apomorphine – pharmacological properties and clinical trials in Parkinson’s disease; Parkinsonism. Related. Disord., 33 Suppl. 1:S13 |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|