ChemicalBook--->CAS DataBase List--->1404-19-9

1404-19-9

1404-19-9 Structure

1404-19-9 Structure
IdentificationBack Directory
[Name]

OLIGOMYCIN
[CAS]

1404-19-9
[Synonyms]

OLIGOMYCIN
OLIGOMYCIN ABC
OLIGOMYCINPURE
Nystatin dehydrate
diastatochromogenes
OligomycinABCcomplex
Oligomycin from Streptomyces
OLIGOMYCIN, MIXTURE OF A, B AND C
oligomycin from streptomyces diastatochromogenes
OLIGOMYCIN FROM STREPTOMYCES*DIASTATOCHR OMOGENE
OLIGOMYCIN, MIXTURE OF THE COMPONENTS A, B AND C
OLIGOMYCIN, MIXTURE OF A, B AND C, FROM STREPTOMYCES DIASTATOCHROMOGENES
[EINECS(EC#)]

215-767-9
[Molecular Formula]

C45H74O11
[MDL Number]

MFCD01779388
[MOL File]

1404-19-9.mol
[Molecular Weight]

2371.17
Chemical PropertiesBack Directory
[Appearance]

White to pale yellow powder
[Melting point ]

84-100 °C
[density ]

1.143 g/cm3
[storage temp. ]

−20°C
[solubility ]

Soluble in DMSO (up to 300 mg/ml) or in Ethanol (up to 200 mg/ml)
[form ]

White solid
[color ]

White
[Water Solubility ]

Sparingly soluble in water. Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n
[BRN ]

7615308
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard InformationBack Directory
[Chemical Properties]

White to pale yellow powder
[Description]

Oligomycin (1404-19-9) inhibits mitochondrial F1F0?ATP synthase.1?A useful tool for decreasing cellular ATP levels.2?Induces autophagy.3?Stimulates lysosome acidification.4?Oligomycin protects against ischemic kidney in male rats.5
[Uses]

Oligomycin is a specific inhibitor of the mitochondrial ATP-synthase.
[General Description]

A mixture of A, B, and C isomers. A macrolide antibiotic that inhibits membrane-bound mitochondrial ATP synthase, preventing phosphoryl group transfer. Induces apoptosis in cultured human lymphoblastoid and other mammalian cells.
[Biochem/physiol Actions]

Product does not compete with ATP.
[in vitro]

in a549, h1299, h1975, h520, 786-0, h838, and u87mg cancer cell lines, 100 ng/ml oligomycin could completely inhibit oxphos phosphorylation activity and stimulate various levels of glycolysis gains [1]. besides, 5 μg/ml oligomycin could inhibit the f0 part of h+-atp-synthase, and strongly suppress cytochrome c release and apoptosis in hela cells induced by tnf [2]. furthermore, oligomycin could inhibit mitochondrial respiration, and sensitize melanoma cells to cisplatin treatment to inhibit cell invasion [3].
[Enzyme inhibitor]

These macrolide antibiotics from Streptomyces diastatochromogenes have three major members: Oligomycin A (FW = 791.08 g/mol; CAS 14104-19- 9), Oligomycin B (FW = 805.06 g/mol; CAS 11050-94-5), and Oligomycin C (FW = 775.08 g/mol; CAS 11052-72-5). Others include Oligomycin D (also known as rutamycin; FW = 777.05 g/mol; CAS 1404-59-7), Rutamycin B (isolated from Streptomyces aureofaciens (See also Rutamycin)), and Oligomycin E (FW = 822.07 g/mol; CAS 110231-34-0; isolated from Streptomyces sp. MCI-2225). Primary Mode of Inhibitory Action: The oligomycins inhibit the ATP synthesis activity of the mitochondrial FoF1 ATP synthase, defining the “o” (not 0) in the first subscript. The ATPase activity of the isolated F1 complex is unaffected by oligomycins, unlike the Fo portion. Oligomycin-sensitivity conferring ptrotein (OSCP) interacts with other components in the ATP synthase complex and facilitates oligomycin’s binding to the Fo unit. The Fo complex is, in fact, an integral membrane protein that functions as a proton channel. Other Actions: Oligomycins also inhibit Na+/K+-exchanging ATPases that transport sodium ions from the inside to the outside of animal cells while translocating potassium ions in the reverse direction with the concomitant hydrolysis of ATP. Oligomycin inhibits Na+ translocation in vivo (i.e., the enzyme activity is inhibited by stabilizing the Na+ occlusion but not the K+ occlusion). Other Properties: The oligomycins are slightly soluble in water (e.g., oligomycin A has a solubility of 2 μg per 100 mL at 25°C) and are considerable more soluble in water-miscible solvents such as ethanol, acetone, and glacial acetic acid. Target(s): aldehyde oxidase; ammonia kinase; apyrase, membrane-bound; ATP synthase, or FoF1 ATP synthase; calcidiol 1-monooxygenase; copper-exporting ATPase, partially inhibited; endopeptidase La, weakly inhibited; H+-transporting ATPase, lysosomal; Na+/K+-exchanging ATPase (24- 32); nucleoside triphosphatase; photophosphorylation in Rhodospirillum rubrum; xenobiotic-transporting ATPases.
[target]

atp synthase
[References]

1) Antoniel?et al. (2014),?The oligomycin-sensitivity conferring protein of mitochondrial ATP synthase: emerging new roles in mitochondrial pathophysiology;? J. Mol. Sci.,?15?7513 2) Ng et al. (2014),?Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity;? Mol. Cell Biol.,?34?1427 3) Tettamonti?et al. (2006),?Oligomycin A induces autophagy in the IPLB-LdFB insect cell line;? Cell Tissue Res.,?326?179 4) van Dyke?et al. (1993),?Acidification of rat liver lysosomes:quantification and comparison with endosomes;? Am. J. Physiol.,?265?C901 5) Tanaka?et al. (2013),?Oligomycin, an F1Fo-ATPase inhibitor, protects against ischemic acute kidney injury in male but not in female rats;? J. Pharmacol. Sci.,?123?227
Safety DataBack Directory
[Hazard Codes ]

Xn,T
[Risk Statements ]

22
[Safety Statements ]

24/25
[RIDADR ]

2811
[WGK Germany ]

3
[RTECS ]

RK3325000
[F ]

3-10
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[HS Code ]

29419090
Spectrum DetailBack Directory
[Spectrum Detail]

OLIGOMYCIN(1404-19-9)IR
OLIGOMYCIN(1404-19-9)Raman
1404-19-9 suppliers list
Company Name: Shenzhen Excellent Biotech Co., Ltd.
Tel: 13480692018
Website: www.chemicalbook.com/ShowSupplierProductsList1588779/0.htm
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674; , 15093356674;
Website: http://www.coreychem.com
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-81138252 +86-18789408387 , +86-18789408387
Website: www.chemicalbook.com/manufacturer/shaanxi-dideu-medichem-222/
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167 , +86-18192503167
Website: www.dideu.com
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: www.dideu.com
Company Name: XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
Tel: +86-029-86333380 18829239519 , 18829239519
Website: https://www.tgybiotech.com/
Company Name: BOC Sciences
Tel: +16314854226 , +16314854226
Website: https://www.bocsci.com/
Company Name: Wuhan Golt Biotech Co., Ltd.
Tel: +8615389281203 , +8615389281203
Website: www.goltbiotech.com
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
Tel: +undefined18621343501 , +undefined18621343501
Website: www.acmec.com.cn/
Company Name: Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Tel: +8613119157289 , +8613119157289
Website: www.cuikangmed.com/
Company Name: Shanghai Yingxin laboratory equipment Co., Ltd  Gold
Tel: 021-021-59178156 15300768757
Website: www.yingxinbio.com/
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  Gold
Tel: 021-52996696,15000506266 15000506266
Website: http://www.bioll.com
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Website: http://www.jkchemical.com
Company Name: Meryer (Shanghai) Chemical Technology Co., Ltd.  
Tel: 4006608290; 18621169109
Website: https://www.meryer.com/cn/index/
Company Name: Dalian Meilun Biotech Co., Ltd.  
Tel: 0411-62910999 13889544652
Website: http://www.meilune.com/
Company Name: ShangHai YuanYe Biotechnology Co., Ltd.  
Tel: 021-61312847 13636370518
Website: www.shyuanye.com
Company Name: Chengdu Ai Keda Chemical Technology Co., Ltd.  
Tel: 4008-755-333 18080918076
Website: http://www.aikeshiji.com
Company Name: Thermo Fisher Scientific  
Tel: 800-810-5118
Website: www.thermo.com.cn
Tags:1404-19-9 Related Product Information
7188-38-7 14542-93-9 645-96-5 2999-46-4 2769-64-4 36635-61-7 39687-95-1