| Identification | Back Directory | [Name]
(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide | [CAS]
140405-36-3 | [Synonyms]
RSVA 405
(Z)-N-(4-(diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide
2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid | [Molecular Formula]
C17H20N4O2 | [MOL File]
140405-36-3.mol | [Molecular Weight]
312.37 |
| Chemical Properties | Back Directory | [density ]
1.16±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
<15.62mg/ml in DMSO | [form ]
Solid | [pka]
8.52±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
RSVA 405 is a potent STAT3 inhibitor and is an analog of resveratol. | [in vivo]
RSVA405 (3 mg/kg; i.p.) attenuates renal injury and protects renal function after ischemia-reperfusion (I/R) in rats[1].
RSVA405 (20-100 mg/kg/d; p.o. for 11 weeks) significantly reduces the body weight gain of mice fed a high-fat diet[2]. | Animal Model: | Male Sprague-Dawley rats (300-350 g) are induced I/R injury[1] | | Dosage: | 3 mg/kg | | Administration: | I.p. one hour before inducing I/R injury | | Result: | Decreased the levels of creatinine and blood urea nitrogen (BUN), by 35.8% and 44.3% in serum, respectively.
Decreased the levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) by 33.0% and 59.8% in serum, respectively.
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| [IC 50]
AMPK: 1 μM (EC50, in cell-based assays) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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