| Identification | Back Directory | [Name]
JNK inhibitor | [CAS]
1408064-71-0 | [Synonyms]
CS-2418
JNK-IN-7
JNK inhibitor
JNK inhibitor 7
JNK-IN-7 Only for R&D
3-(4-(Dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
(E)-3-(4-(dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
Benzamide, 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]- | [Molecular Formula]
C28H27N7O2 | [MDL Number]
MFCD25976765 | [MOL File]
1408064-71-0.mol | [Molecular Weight]
493.56 |
| Chemical Properties | Back Directory | [density ]
1.301±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH | [form ]
solid | [pka]
13.34±0.70(Predicted) | [color ]
White to gray |
| Hazard Information | Back Directory | [Description]
JNK inhibitor VII is a potent and non-selective inhibitor of JNKs (IC50s = 1.54, 1.99, and 0.75 nM for JNK1, -2, and -3, respectively). It inhibits phosphorylation of c-Jun in HeLa and A375 cells (EC50s = 130 and 244 nM, respectively). | [Uses]
JNK Inhibitor IX is a potent and selective inhibitor of JNK2 and JNK3. Neuroresearch & Neuroprotective Product. | [IC 50]
JNK3: 0.7 nM (IC50); JNK1: 1.5 nM (IC50); JNK2: 2 nM (IC50) | [storage]
Store at -20°C | [References]
[1]. zhang t, inesta-vaquera f, niepel m et al. discovery of potent and selective covalent inhibitors of jnk. chem biol. 2012 jan 27;19(1):140-54.
[2]. goh et, arthur js, cheung pc et al. identification of the protein kinases that activate the e3 ubiquitin ligase pellino 1 in the innate immune system. biochem j. 2012 jan 1;441(1):339-46. |
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NCE Biomedical Co.,Ltd.
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