| Identification | Back Directory | [Name]
LY 231617 | [CAS]
141545-89-3 | [Synonyms]
LY 231617
2,6-di-tert-butyl-4-((ethylamino)methyl)phenol hydrochloride
2,6-BIS(1,1-DIMETHYLETHYL)-4-[[(1-ETHYL)AMINO]METHYL]PHENOL, HCL
2,6-bis(1,1-Dimethylethyl)-4-[(ethylamino)methyl]phenol hydrochloride | [Molecular Formula]
C17H30ClNO | [MDL Number]
MFCD00919199 | [MOL File]
141545-89-3.mol | [Molecular Weight]
299.88 |
| Hazard Information | Back Directory | [Uses]
LY 231617 is an antioxidant and is able to prevent ischaemia-induced neurodegeneration. LY 231617 is a neuroprotective and an anti-ischaemic agent. | [in vivo]
LY231617 (50 mg/kg; p.o. 30 minutes before occlusion) reduces global ischemic neuronal injury in rats[2].
LY231617 (20 mg/kg; i.v. 30 minutes after occlusion) protects hippocampus and striatum from four-vessel occlusion[2]. | Animal Model: | Male Wistar rats four-vessel occlusion[2] | | Dosage: | 50 mg/kg | | Administration: | Oral gavage; 50 mg/kg 30 minutes before occlusion | | Result: | Significantly protected both the hippocampus and striatum from 30 minutes of four-vessel occlusion.
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| Animal Model: | Male Wistar rats four-vessel occlusion[2] | | Dosage: | 20 mg/kg | | Administration: | Intravenous injection ; 20 mg/kg 30 minutes after occlusion | | Result: | Significantly protected the hippocampus and the striatum when given 30 minutes after the onset of the ischemia at the time of reperfusion.
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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