| Identification | Back Directory | [Name]
11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt | [CAS]
1421610-21-0 | [Synonyms]
JNK Inhibitor XV
11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt | [Molecular Formula]
C15H10N3NaO | [MDL Number]
MFCD30182320 | [MOL File]
1421610-21-0.mol | [Molecular Weight]
271.25 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 15 mg/ml) | [form ]
solid | [color ]
Yellow | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosuppressive activity. Inhibits LPS-induced proinflammatory cytokine and nitric oxide release?in vitro.1?Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity?in vivo.2 | [Uses]
IQ 1S is a JNK inhibitor which inhibits LPS-induced proinflammatory. | [in vivo]
When mice are dosed with 12.5 and 30 mg/kg IQ-1S (The sodium salt of IQ-1) i.p., the serum exposure of the compound is also good, with AUC0-12h values of 2.9 and 7.4 μM/h, respectively[1]. | [IC 50]
JNK3: 87 nM (Kd); JNK2: 360 nM (Kd); JNK1: 390 nM (Kd); PI3Kγ: 1.2 μM (Kd); CK1δ: 1.4 μM (Kd); MKNK2: 1.8 μM (Kd) | [References]
1) Schepetkin?et al.?(2012),?Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors; Mol. Pharmacol.,?81?832
2) Schepetkin?et al.?(2015),?Anti-Inflammatory effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1A, a Selective c-Jun N-Terminal Kinase Inhibitor; J. Pharmacol. Exp. Ther.,?353?505 |
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| Company Name: |
BOC Sciences
|
| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
Abcam Limited
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| Tel: |
021-2070050 400921018 |
| Website: |
www.abcam.cn |
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