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50-02-2

50-02-2 Structure

50-02-2 Structure
IdentificationMore
[Name]

Dexamethasone
[CAS]

50-02-2
[Synonyms]

(11B,16A)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-PREGNA-1,4-DIENE-3,20-DIONE
(11BETA,16ALPHA)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE
1,4-PREGNADIEN-9ALPHA-FLUORO-16ALPHA-METHYL-11BETA, 17ALPHA, 21-TRIOL 3,20-DIONE
1,4-PREGNADIENE-3,20-DIONE-9ALPHA-FLUORO-16ALPHA METHYL-11BETA,17ALPHA,21-TRIOL
9ALPHA-FLUORO-11BETA,17,21-TRIHYDROXY-16ALPHA-METHYL-1,4-PREGNADIENE 3,20DIONE
9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIHYDROXY-16ALPHA-METHYLPREGN-1,4-DIENE-3,20-DIONE
9ALPHA-FLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE
9ALPHA-FLUORO-16ALPHA-METHYLPREDNISOLONE
CALONAT
DECACORTIN
DECADRON
DECASONE
DERONIL
DEXAMETHASON
DEXAMETHASONE
DEXAMETHASONE BASE
DEXAMETHASONUM
HEXADECADROL
PREDNISOLONE F
[EINECS(EC#)]

200-003-9
[Molecular Formula]

C22H29FO5
[MDL Number]

MFCD00064136
[Molecular Weight]

392.46
[MOL File]

50-02-2.mol
Chemical PropertiesBack Directory
[Appearance]

White Crystalline Solid
[Appearance]

White or almost white, crystalline powder.
[mp ]

262-264 °C(lit.)
[alpha ]

75 º (c=1, dioxane)
[refractive index ]

76 ° (C=1, Dioxane)
[storage temp. ]

2-8°C
[solubility ]

ethanol: 1 mg/mL
[form ]

powder
[color ]

off-white
[Stability:]

Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive.
[Water Solubility ]

10 mg/100 mL (25 ºC)
[Usage]

A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase
[Merck ]

14,2943
[BRN ]

2066651
[CAS DataBase Reference]

50-02-2(CAS DataBase Reference)
[NIST Chemistry Reference]

Prednisolone, 9alpha-fluoro-16alpha-methyl-(50-02-2)
[EPA Substance Registry System]

50-02-2(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xi,Xn
[Risk Statements ]

R43:May cause sensitization by skin contact.
R40:Limited evidence of a carcinogenic effect.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
[Safety Statements ]

S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S22:Do not breathe dust .
[WGK Germany ]

2
[RTECS ]

TU3980000
[HS Code ]

29372200
[Safety Profile]

Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of F-.
[Hazardous Substances Data]

50-02-2(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Preparation Products]

BECLOMETHASONE
Hazard InformationBack Directory
[General Description]

Odorless white to off-white crystalline powder with a slightly bitter taste.
[Reactivity Profile]

DEXAMETHAZONE(50-02-2) may be sensitive to prolonged exposure to light. This chemical is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides. Oxidation may occur with bases.
[Air & Water Reactions]

Insoluble in water.
[Fire Hazard]

Flash point data for this chemical are not available; however, DEXAMETHAZONE is probably combustible.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione(50-02-2).msds
Questions And AnswerBack Directory
[Description]

Dexamethasone is an Anti-inflammatory glucocorticoid that is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide.
Dexamethasone induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cd k2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein in vitro. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils in vitro. Dexamethasone is an activator of IDO.
Dexamethasone Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC50=5 nM). Dexamethasone regulates T cell survival, growth, and differentiation.Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37°C.
[Side Effects]

Dexamethasone is a artificially synthetic glucocorticoid, belonging to a long-term glucocorticoid drugs. Glucocorticoids can promote the metabolism of the three major nutrients while preventing protein synthesis with long-term topical being able to causing more serious consequences. However, the adverse effects should be much smaller than oral medication. Common side effects of systemic corticosteroid include:
It can cause stomach discomfort and increased sensitivity to stomach ulcers.
It can Increase the appetite and results in a significant increase in body weight.
Potential patients with diabetes: glucose intolerance in patients with aggravating existing diabetes.
It can cause mental illness including personality changes, irritability, agitation, and mania.
It can be used for the long-term treatment of osteoporosis: pathological fractures (such as hip).
It can cause elevated liver enzymes, fatty liver degeneration (usually reversible).
For patients of nephrotic syndrome, applying long-term high-dose medication is likely to cause large side effects such as gastrointestinal ulcers and avascular necrosis. For treatment of nephrotic syndrome, it is better to apply prednisone acetate tablets.
Dexamethasone can be used for the treatment of high altitude cerebral edema and pulmonary edema. Upon climbing expeditions, people can apply it to alleviate altitude sickness.
Combination with marbofloxacin and clotrimazole, etc. can be used for treating the ear infection and allergies of a dog or a bird.
The above information is edited by the chemicalbook of Dai Xiongfeng.
[Drug Reactions]

Dexamethasone is a corticosteroid known as a glucocorticoid. Corticosteroids are meant to resemble a naturally occurring hormone produced in the adrenal cortex, cortisol. Corticosteroids act on the immune system by blocking the production of substances that trigger inflammatory and immune responses.
Dexamethasone may react with these drugs:
Amphotericin
Aspirin
Cyclophosphamide
Cyclosporine
Digoxin
Daunorubicin HCl
Doxorubicin HCl
Insulin
Mitotane
Phenobarbital
Phenytoin sodium
Rifampin
Rimadyl
Spectrum DetailBack Directory
[Spectrum Detail]

Dexamethasone(50-02-2) 1H NMR
Dexamethasone(50-02-2) MS
Dexamethasone(50-02-2) IR1
Dexamethasone(50-02-2) IR2
Dexamethasone(50-02-2) 13C NMR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Dexamethasone, 96%(50-02-2)
[Alfa Aesar]

Dexamethasone, 98%(50-02-2)
[Sigma Aldrich]

50-02-2(sigmaaldrich)
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