| Identification | Back Directory | [Name]
1422253-38-0 | [CAS]
1422253-38-0 | [Synonyms]
4-(((6S,9S,9AS)-1-(BENZYLCARBAMOYL)-2,9-DIMETHYL-4,7-DIOXO-8- (QUINOLIN-8-YLMETHYL)OCTAHYDRO-2H-PYRA
4-(((6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8- (quinolin-8-ylmethyl)octahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl) methyl)phenyl dihydrogen phosphate
2H-Pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide, hexahydro-2,9-dimethyl-4,7-dioxo-N-(phenylmethyl)-6-[[4-(phosphonooxy)phenyl]methyl]-8-(8-quinolinylmethyl)-, (6S,9S,9aS)- | [Molecular Formula]
C33H35N6O7P | [MOL File]
1422253-38-0.mol | [Molecular Weight]
658.64 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [solubility ]
DMSO: Soluble: =10 mg/ml | [form ]
Solid | [pka]
1.26±0.30(Predicted) | [color ]
White to off-white | [InChIKey]
VHOZWHQPEJGPCC-AZXNYEMZSA-N | [SMILES]
N1(C)CC(=O)N2[C@@H](CC3=CC=C(OP(O)(O)=O)C=C3)C(=O)N(CC3=C4C(=CC=C3)C=CC=N4)[C@@H](C)[C@]2([H])N1C(NCC1=CC=CC=C1)=O |
| Hazard Information | Back Directory | [Uses]
PRI 724 is a studied as a prospect for safely and effectively targeting catenin coactivator antagonism interactions to eliminate cancer stem cell population in human cancer. | [in vivo]
PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo. PRI-724 treatment reduces the fibrosis induced by CCl4 or BDL. C-82, an active form of PRI-724, inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1]. | [References]
[1] Y. OSAWA. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice[J]. EBioMedicine, 2015, 58 1: 1751-1758. DOI: 10.1016/j.ebiom.2015.10.010
[2] ZEYUAN YU. A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination[J]. Oncogene, 2020, 40 5: 1027-1042. DOI: 10.1038/s41388-020-01572-w
[3] ROBERT KLESZCZ Jarosław P. The Wnt Signaling Pathway Inhibitors Improve the Therapeutic Activity of Glycolysis Modulators against Tongue Cancer Cells.[J]. International Journal of Molecular Sciences, 2022, 23 3. DOI: 10.3390/ijms23031248
[4] M MAVIGNER. Pharmacological Modulation of the Wnt/β-Catenin Pathway Inhibits Proliferation and Promotes Differentiation of Long-Lived Memory CD4+ T Cells in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques.[J]. Journal of Virology, 2019, 94 1. DOI: 10.1128/jvi.01094-19 |
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| Company Name: |
Twochem Co.Ltd.
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| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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