ChemicalBook--->CAS DataBase List--->142326-59-8

142326-59-8

142326-59-8 Structure

142326-59-8 Structure
IdentificationBack Directory
[Name]

L-701,324
[CAS]

142326-59-8
[Synonyms]

L-701
CS-2045
L-701,324
L-701,304
7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(H)-quinolinone
7-chloro-1-(4-hydroxy-3-phenoxyphenyl)quinolin-2(1H)-one
7-CHLORO-4-HYDROXY-3-(3-PHENOXY)PHENYL-2(1H)-QUINOLINONE
7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one
7-CHLORO-4-HYDROXY-3-(3-PHENOXY )PHENYLQUINOLIN-2[1H]-ONE
2(1H)-Quinolinone, 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-
[Molecular Formula]

C21H14ClNO3
[MDL Number]

MFCD00910917
[MOL File]

142326-59-8.mol
[Molecular Weight]

363.79
Chemical PropertiesBack Directory
[Melting point ]

308 °C
[Boiling point ]

584.7±50.0 °C(Predicted)
[density ]

1.389±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

DMSO: soluble36.4mg/mL
[form ]

solid
[pka]

4.50±1.00(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

L-701,324 is a potential anticonvulsant with high selectivity and affinity for the NMDA receptor glycine site. NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment.
[Definition]

ChEBI: 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one is a member of quinolines.
[Biological Activity]

An orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
[in vivo]

L-701324 (5-10 mg/kg; i.p.; once) exhibits antidepressant-like potential in the forced swim test (FST) and tail suspension test (TST) without affecting the locomotor activity of mice[1].
L-701324 (5-10 mg/kg; i.p.; daily, for 2 weeks) produces strong antidepressant-like effects in the chronic unpredictable mild stress (CUMS) model of depression and prevents the CUMS-induced decreases in eurogenesis and the BDNF signaling cascade in the hippocampus[1].
L-701324 (2.5-5 mg/kg; p.o.; once) inhibits NMDA receptor activity via a blockade of the NMDA/glycine-sensitive site at the NMDA receptor is accompanied by a reduction of anxiety-like behavior in both non-conditioned and conditioned conflict behavior situations[2].

Animal Model:Male C57BL/6 J mice in the chronic unpredictable mild stress (CUMS) (7 weeks of age) [1]
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; daily, for 2 weeks
Result:Reduced the immobility of C57BL/6 J mice.
Increased the expression of BDNF, pTrkB and pCREB in the hippocampus.
Animal Model:Male C57BL/6 J mice in the forced swim test (FST) and tail suspension test (TST) (7 weeks of age)[1]
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; once
Result:Reduced the immobility of C57BL/6 J mice in the FST and TST.
Animal Model:Male Sprague-Dawley rats (280-300 g)[2]
Dosage:2.5 and 5 mg/kg
Administration:Oral administration; once
Result:Increased in the percentage of time spent in the open arm in a dose-dependent.
Increased punished responding in the Vogel's conflict test in a dose-dependent fashion.
[IC 50]

NMDA Receptor
[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

L-701,324(142326-59-8)1HNMR
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