| Identification | Back Directory | [Name]
AMpicillin-d5 | [CAS]
1426173-65-0 | [Synonyms]
AMpicillin-d5
[2H5]-Ampicillin
(Mixture of Diastereomers) | [Molecular Formula]
C16H14D5N3O4S | [MDL Number]
MFCD19704897 | [MOL File]
1426173-65-0.mol | [Molecular Weight]
354.436 |
| Hazard Information | Back Directory | [Description]
Ampicillin-d5 is intended for use as an internal standard for the quantification of ampicillin by GC- or LC-MS. Ampicillin is a broad-spectrum antibiotic with activity against Gram-positive and Gram-negative bacteria, including veterinary isolates of S. pseudintermedius, S. aureus, E. coli, Pasteurella, and S. canis (MIC50s = 0.25, 0.5, 2, 0.12, and 0.25 μg/ml, respectively).1 In vivo, ampicillin (80 mg/kg, i.v.) reduces cough frequency, tachypnea, dyspnea, and fever and increases survival in a baboon (P. cynocephalus) model of pneumococcal pneumonia.2 Formulations containing ampicillin have been used to treat a variety of bacterial infections. | [Uses]
Labelled Ampicillin. Orally active, semi-synthetic antibiotic | [IC 50]
β-lactam | [References]
1. Awji, E.G., Damte, D., Lee, S.-J., et al. The in vitro activity of 15 antimicrobial agents against bacterial isolates from dogs J. Vet. Med. Sci. 74(8),1091-1094(2012).
2. Reyes, L.F., Restrepo, M.I., Hinojosa, C.A., et al. A non-human primate model of severe pneumococcal pneumonia PLoS One 11(11),e0166092(2016). |
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