ChemicalBook--->CAS DataBase List--->875-74-1

875-74-1

875-74-1 Structure

875-74-1 Structure
IdentificationMore
[Name]

D-2-Phenylglycine
[CAS]

875-74-1
[Synonyms]

D-(-)-2-PHENYLGLYCINE
D-2-PHENYLGLYCINE
D-(-)-A-AMINOPHENYLACETIC ACID
D(-)-ALPHA-AMINOPHENYLACETIC ACID
D-ALPHA-AMINOPHENYLACETIC ACID
(-)-D-ALPHA-PHENYLGLYCINE
D(-)-ALPHA-PHENYLGLYCINE
D-ALPHA-PHENYLGLYCINE
D-AMINOPHENYLACETIC ACID
D-(-)-A-PHENYLAMINOACETIC ACID
D-(-)-A-PHENYLGLYCINE
D-(-)-PHENYLGLYCINE
D-PHENYLGLYCINE
H-D-(PHENYL)GLY-OH
H-D-PHG-OH
PHENYLGLYCINE-D
(R)-(-)-2-PHENYLGLYCINE
(R)-(-)-ALPHA-AMINOPHENYLACETIC ACID
(R)-ALPHA-AMINOPHENYLACETIC ACID
(R)-(-)-ALPHA-PHENYLAMINOACETIC ACID
[EINECS(EC#)]

212-876-3
[Molecular Formula]

C8H9NO2
[MDL Number]

MFCD00008061
[Molecular Weight]

151.16
[MOL File]

875-74-1.mol
Chemical PropertiesBack Directory
[Appearance]

White crystalline powder
[Melting point ]

302 °C (dec.)(lit.)
[alpha ]

-156 º (c=1,1N HCl)
[Boiling point ]

273.17°C (rough estimate)
[density ]

1.2 g/cm3 (20℃)
[vapor pressure ]

0Pa at 25℃
[refractive index ]

-158 ° (C=1, 1mol/L HCl)
[Fp ]

150 °C
[storage temp. ]

Store at RT.
[solubility ]

Aqueous Acid (Sparingly), Water (Slightly, Heated)
[form ]

Crystalline Powder
[pka]

1.94±0.10(Predicted)
[color ]

White
[Optical Rotation]

[α]20/D 155°, c = 1 in 1 M HCl
[Water Solubility ]

0.3g/100mL
[Merck ]

14,7291
[BRN ]

2208676
[Major Application]

detection
[InChI]

1S/C8H9NO2/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H,10,11)/t7-/m1/s1
[InChIKey]

ZGUNAGUHMKGQNY-SSDOTTSWSA-N
[SMILES]

N[C@@H](C(O)=O)c1ccccc1
[LogP]

-1.76 at 20℃
[CAS DataBase Reference]

875-74-1(CAS DataBase Reference)
[NIST Chemistry Reference]

d a-Phenylglycine(875-74-1)
[EPA Substance Registry System]

875-74-1(EPA Substance)
Questions And AnswerBack Directory
[Description]

L-phenylglycine (Cephalexin EP Impurity A) is a derivative of glycine, a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in the spinal cord and an allosteric modulator of NMDA receptors.
[Storage]

Store at room temperature. Store in cool dry place in tightly closed container. Store away from oxidizing agent.
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H335-H319-H315
[Precautionary statements ]

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
[Hazard Codes ]

T
[Risk Statements ]

R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
[WGK Germany ]

3
[TSCA ]

Yes
[REACH Registrations]

Active
[HS Code ]

29224995
[Storage Class]

11 - Combustible Solids
Raw materials And Preparation ProductsBack Directory
[Preparation Products]

Ampicillin-->(2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-phenylacetic acid-->1R,3R-chrysanthemic acid-->(R)-(-)-2-Phenylglycine chloride hydrochloride-->Potassium (R)-[(3-ethoxy-1-methyl-3-oxoprop-1-enyl)amino]phenylacetate-->FMOC-D-PHG-OH-->Benzeneacetic acid, α-(diethylamino)-, (αR)--->Benzeneacetic acid, α-[(1-methylethyl)amino]-, (R)- (9CI)
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

D(-)-alpha-Phenylglycine(875-74-1).msds
Hazard InformationBack Directory
[Chemical Properties]

White crystalline powder
[Uses]

D-(-)-2-Phenylglycine is the derivative of glycine (G615990), a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA r eceptors.
[Definition]

ChEBI: The R stereoisomer of alpha-phenylglycine.
[Flammability and Explosibility]

Nonflammable
[reaction suitability]

reaction type: solution phase peptide synthesis
[Synthesis]

Industrially, dphenylglycine has been produced by a conventional resolution method or by kinetic resolution with acylase. Another enzymatic procedure has been developed by Yamada et al. , as shown below.
Synthesis_875-74-1
Spectrum DetailBack Directory
[Spectrum Detail]

D-2-Phenylglycine(875-74-1)1HNMR
D-2-Phenylglycine(875-74-1)IR1
D-2-Phenylglycine(875-74-1)IR2
D-2-Phenylglycine(875-74-1)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

D(-)-alpha-Phenylglycine, 98%(875-74-1)
[Alfa Aesar]

D-(-)-2-Phenylglycine, 99%(875-74-1)
[Sigma Aldrich]

875-74-1(sigmaaldrich)
[TCI AMERICA]

D-2-Phenylglycine,>99.0%(T)(875-74-1)
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