1426916-02-0

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1426916-02-0 Structure

Identification	Back Directory
[Name] ML298
[CAS] 1426916-02-0
[Synonyms] ML298 ML298 >=98% (HPLC) Benzamide, 3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-
[Molecular Formula] C22H23F3N4O2
[MOL File] 1426916-02-0.mol
[Molecular Weight] 432.44

Chemical Properties	Back Directory
[storage temp. ] 2-8°C
[solubility ] DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml
[form ] powder
[color ] white to beige

Safety Data	Back Directory
[WGK Germany ] 3

Hazard Information	Back Directory
[Description] ML-298 is an inhibitor of phospholipase D₂ (PLD₂; IC₅₀ = 355 nM). It is selective for PLD₂ over PLD₁ (IC₅₀ = 20,000 nM). It decreases invasive migration of U87-MG glioblastoma cells when used at a concentration of 10 μM without inducing cytotoxicity.
[Uses] ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2).
[Biochem/physiol Actions] ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2; IC50 = 355 nM). ML298 does not affect PLD1 activity at concentrations up to 20 μM.
[storage] Store at -20°C

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